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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HNF4A
All Species:
16.36
Human Site:
S378
Identified Species:
30
UniProt:
P41235
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P41235
NP_849180.1
474
52785
S378
Q
E
M
L
L
G
G
S
P
S
D
A
P
H
A
Chimpanzee
Pan troglodytes
XP_514664
468
51900
M377
I
D
N
L
L
Q
E
M
L
L
G
G
S
S
S
Rhesus Macaque
Macaca mulatta
XP_001110097
452
49945
M361
I
D
N
L
L
Q
E
M
L
L
G
G
S
S
S
Dog
Lupus familis
XP_852731
474
52640
S378
Q
E
M
L
L
G
G
S
S
S
D
A
P
H
A
Cat
Felis silvestris
Mouse
Mus musculus
P49698
474
52665
S378
Q
E
M
L
L
G
G
S
A
S
D
A
P
H
T
Rat
Rattus norvegicus
P22449
474
52693
S378
Q
E
M
L
L
G
G
S
A
S
D
A
P
H
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507309
419
46844
S330
I
S
D
R
Q
H
D
S
R
G
R
F
G
E
L
Chicken
Gallus gallus
NP_001026026
454
50607
A354
F
V
K
L
F
G
M
A
K
I
D
N
L
L
Q
Frog
Xenopus laevis
Q91766
464
51948
A363
F
V
K
L
F
G
M
A
K
I
D
N
L
L
Q
Zebra Danio
Brachydanio rerio
A2T929
430
47452
L338
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49866
666
71882
E433
Q
E
M
L
L
G
G
E
L
A
D
N
P
L
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O44960
369
41820
S279
G
I
T
S
E
S
Y
S
D
V
E
E
M
R
Q
Sea Urchin
Strong. purpuratus
XP_780389
468
51669
S349
Q
E
M
L
L
G
G
S
A
N
D
P
S
Q
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.6
90.9
98.3
N.A.
95.7
96.1
N.A.
79.5
84.1
80.8
33.7
N.A.
42.4
N.A.
33.9
57.1
Protein Similarity:
100
82.9
91.9
99.1
N.A.
97
97.4
N.A.
84.8
89.8
89.6
51.4
N.A.
54.5
N.A.
49.5
72.3
P-Site Identity:
100
13.3
13.3
93.3
N.A.
86.6
93.3
N.A.
6.6
20
20
13.3
N.A.
60
N.A.
6.6
60
P-Site Similarity:
100
26.6
26.6
93.3
N.A.
86.6
93.3
N.A.
6.6
26.6
26.6
26.6
N.A.
66.6
N.A.
13.3
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
16
24
16
0
31
0
0
24
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
8
16
8
0
0
0
8
0
8
0
62
0
0
0
0
% D
% Glu:
0
47
0
8
8
0
16
8
0
0
8
8
0
8
0
% E
% Phe:
16
0
0
0
16
0
0
0
0
0
0
8
0
8
0
% F
% Gly:
8
0
0
0
0
70
47
0
0
8
16
16
8
0
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
31
0
% H
% Ile:
24
8
0
0
0
0
0
0
0
16
8
0
0
0
0
% I
% Lys:
0
8
16
0
0
0
0
0
16
0
0
0
0
0
0
% K
% Leu:
0
0
0
77
70
0
0
8
24
16
0
0
24
24
8
% L
% Met:
0
0
47
0
0
0
16
16
0
0
0
0
8
0
0
% M
% Asn:
0
0
16
0
0
0
0
0
0
8
0
24
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
0
8
39
0
8
% P
% Gln:
47
0
0
0
8
16
0
0
0
0
0
0
0
8
31
% Q
% Arg:
0
0
0
8
0
0
0
0
16
0
8
0
0
8
0
% R
% Ser:
0
8
0
8
0
8
0
54
8
31
0
0
24
16
16
% S
% Thr:
0
0
16
0
0
0
0
0
0
0
0
0
0
0
8
% T
% Val:
0
16
0
0
0
0
0
0
0
8
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _